| 13:10 | Dodgers | Clayton Kershaw | 5-2 3.29 | @ | Rays | Drew Rasmussen | 8-5 2.96 | ||
| 14:20 | Orioles | Tomoyuki Sugano | 8-5 4.38 | @ | Cubs | Ben Brown | 5-7 6.22 | ||
| 15:07 | Royals | Kris Bubic | 8-7 2.55 | @ | Blue Jays | Max Scherzer | 1-1 4.89 | ||
| 15:10 | Pirates | Paul Skenes | 6-8 1.83 | @ | Rockies | Austin Gomber | 0-5 6.28 | ||
| 16:05 | Brewers | Jose Quintana | 8-4 3.50 | @ | Nationals | Jake Irvin | 8-5 4.69 | ||
| 16:05 | Tigers | Jack Flaherty | 6-10 4.36 | @ | Phillies | Zack Wheeler | 9-4 2.56 | ||
| 16:10 | Twins | Joe Ryan | 10-5 2.83 | @ | Guardians | Gavin Williams | 6-4 3.33 | ||
| 16:10 | Rangers | Jacob deGrom | 10-3 2.55 | @ | Mariners | Luis Castillo | 8-6 3.43 | ||
| 16:10 | Yankees | Max Fried | 12-4 2.62 | @ | Marlins | Eury Pérez | 3-3 3.07 | ||
| 16:10 | Giants | Carson Seymour | 0-1 4.00 | @ | Mets | Kodai Senga | 7-3 2.00 | ||
| 16:10 | Astros | Colton Gordon | 4-3 4.74 | @ | Red Sox | Walker Buehler | 6-6 5.72 | ||
| 19:15 | Braves | Dane Dunning | 0-0 7.16 | @ | Reds | Chase Burns | 0-3 6.26 | ||
| 22:05 | Diamondbacks | Zac Gallen | 7-12 5.60 | @ | Athletics | J.T. Ginn | 2-2 3.89 | ||
| 22:07 | White Sox | Sean Burke | 4-8 4.17 | @ | Angels | Kyle Hendricks | 6-7 4.72 | ||
| 22:10 | Cardinals | Michael McGreevy | 2-2 4.91 | @ | Padres | TBD |