| 12:35 | Blue Jays | José Berríos | 7-4 3.83 | @ | Orioles | Dean Kremer | 8-7 4.23 | ||
| 13:10 | Diamondbacks | Ryne Nelson | 6-2 3.29 | @ | Tigers | Reese Olson | 4-4 3.15 | ||
| 13:10 | Red Sox | Brayan Bello | 7-5 3.33 | @ | Twins | Bailey Ober | 4-6 5.28 | ||
| 14:10 | Nationals | MacKenzie Gore | 4-10 3.52 | @ | Astros | Ryan Gusto | 6-4 5.17 | ||
| 14:10 | Cubs | Shota Imanaga | 7-4 3.12 | @ | Brewers | Freddy Peralta | 12-4 2.81 | ||
| 14:10 | Braves | Joey Wentz | 2-2 5.76 | @ | Royals | TBD | |||
| 14:10 | Phillies | Taijuan Walker | 3-5 3.84 | @ | White Sox | Adrian Houser | 6-2 2.10 | ||
| 15:45 | Pirates | Mike Burrows | 1-3 4.15 | @ | Giants | Logan Webb | 9-8 3.38 | ||
| 16:10 | Mets | Clay Holmes | 9-5 3.40 | @ | Padres | Nick Pivetta | 10-3 2.81 | ||
| 18:40 | Rockies | Kyle Freeland | 2-10 5.24 | @ | Guardians | Doug Nikhazy | 0-1 13.50 | ||
| 19:05 | Rays | Zack Littell | 8-8 3.72 | @ | Yankees | Will Warren | 6-5 4.82 | ||
| 19:10 | Dodgers | Shohei Ohtani | 0-0 1.50 | @ | Reds | Nick Martinez | 7-9 4.82 | ||
| 19:45 | Marlins | Cal Quantrill | 3-8 5.05 | @ | Cardinals | Miles Mikolas | 6-7 4.94 | ||
| 21:38 | Rangers | Nathan Eovaldi | 8-3 1.50 | @ | Angels | José Soriano | 7-7 3.79 | ||
| 22:05 | Mariners | Bryan Woo | 8-5 2.91 | @ | Athletics | Jeffrey Springs | 9-7 4.28 |