| Rays | 0 | Cubs | 0 | In Progress - Top 1 |
| 15:07 | Orioles | Trevor Rogers | 8-2 1.43 | @ | Blue Jays | Max Scherzer | 5-3 4.36 | ||
| 16:05 | Pirates | Bubba Chandler | 2-1 7.36 | @ | Nationals | Cade Cavalli | 3-1 4.67 | ||
| 16:10 | Tigers | Charlie Morton | 9-10 5.59 | @ | Marlins | Janson Junk | 6-3 4.48 | ||
| 16:10 | Rangers | Patrick Corbin | 7-9 4.36 | @ | Mets | Tylor Megill | 5-5 3.95 | ||
| 16:10 | Yankees | Max Fried | 16-5 3.02 | @ | Red Sox | Brayan Bello | 12-6 3.14 | ||
| 18:05 | Royals | Ryan Bergert | 2-2 3.48 | @ | Phillies | Taijuan Walker | 4-8 4.03 | ||
| 18:10 | White Sox | Davis Martin | 6-9 4.03 | @ | Guardians | Parker Messick | 2-0 1.93 | ||
| 19:10 | Diamondbacks | Ryne Nelson | 7-3 3.48 | @ | Twins | Joe Ryan | 13-8 3.32 | ||
| 19:15 | Astros | Framber Valdez | 12-9 3.42 | @ | Braves | Joey Wentz | 5-6 5.82 | ||
| 20:15 | Cardinals | Sonny Gray | 13-8 4.45 | @ | Brewers | Brandon Woodruff | 6-3 3.52 | ||
| 20:40 | Rockies | Chase Dollander | 2-12 6.52 | @ | Padres | Yu Darvish | 3-5 5.65 | ||
| 21:05 | Dodgers | Yoshinobu Yamamoto | 11-8 2.55 | @ | Giants | Carson Whisenhunt | 2-1 5.01 | ||
| 21:40 | Angels | Caden Dana | 0-1 6.32 | @ | Mariners | Bryan Woo | 13-7 3.02 | ||
| 22:05 | Reds | Hunter Greene | 6-4 2.59 | @ | Athletics | Luis Severino | 6-11 4.67 |